What is Tryptophan Hydroxylase?
I have recently read articles that describe MDMA as a Tryptophan Hydroxylase inhibitor.
I understand MDMA's effect on Serotonin levels in the brain, but what is Tryptophan Hydroxylase?
Reply from Nick Cozzi
Tryptophan hydroxylase is the rate-limiting enzyme in serotonin
biosynthesis. It is present in serotonergic neurons and it catalyzes the
addition of the 5-hydroxy group to tryptophan to give 5-hydroxytryptophan.
This substance is then decarboxylated to give 5-hydroxytryptamine
Nicholas V. Cozzi, Ph.D.
Department of Pharmacology
University of Wisconsin Medical School