E with St John's Wort, SSRIs and Syrian Rue
A friend of mine started taking St. John's Wort a couple weeks ago and is wondering if there is any contraindication between that and MDMA, since SJW is a mild MAOI and all. I know someone who had a very bad reaction with MDMA + syrian rue, but I remember others taking MDMA + moclobemide and experiencing no bad effects.
Replies from users
SJW is only a pretty mild MAOI, and perhaps also a mild SSRI. The actual
mechanism of action is not known yet, though it (or at least the standardised
extracts) do work pretty well as anti-depressants. I don't know of any reports
of use with MDMA.
Both SJW and tryptophan seem to combat E tolerance, and also help with
mid-week blues. The trytophan is usually taken during the day, then a half
hour before pills.
I took St. John's Wort for a few weeks, and found it mildly helpful as an anti-depressant. I combined it with MDMA only once and found the experience of the 'E' effects to be qualitatively no different. However, I did experience nausea and a persistent nagging headache that lasted through the whole experience. I've combined Prozac and Serzone (both SSRIs) with MDMA with no negative effects.