Is there cross tolerance between MDA, MDMA and MDEA?
I've heard that MDMA and MDA work in different ways, and therefore do not increase each others tolerance. Does the same apply between MDMA and MDEA?
reply from an expert
In general, MDA, MDMA, and MDEA all work the same way, i.e. block uptake and increase release of serotonin and dopamine, albeit with different potencies and selectivities. I am unaware of any controlled studies looking at whether these three drugs are cross-tolerant, but I strongly suspect that they are.
Nicholas V. Cozzi, Ph.D.