E for Ecstasy by Nicholas Saunders
Appendix 1: Reference Section
- 38 Entry in Micromedex, vol. 75, a hospital database printout
from the National Poisons Unit at Guy's Hospital, London
- This entry says that evidence that MDMA is neurotoxic is controversial.
Behavioural alterations have been observed in rats given high doses, but
the rats' behaviour has returned to normal after 4 weeks.
- It reports two cases of lead poisoning resulting from Ecstasy use, which
are put down to toxic by-products of MDMA manufacture. Lead acetate is a
component of one synthesis procedure.
- Urinary excretion of unchanged MDMA and its metabolites is complete
within 24 hours. 65% of the dose is excreted unchanged in the urine and
7% as MDA. Release of dopamine in rats is greatest with MDA, less with MDMA
and least with MDEA. Dopamine release may relate to amphetamine-like side
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