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[Contents][Appendix 1]
[Reference 183][Reference 185]

E is for Ecstasy by Nicholas Saunders

Appendix 1: Reference Section

184 Reinforcing Subjective Effects of MDMA May be Separable from its Neurotoxic Actions by McCann and Ricaurte, J. Clinical Psychopharmacology 6/1993

Subjective trials show that the psychoactive effects of MDMA are not affected by taking fluoxetine first. Serotonin re-uptake inhibitors block MDMA neurotoxicity. Since fluoxetine is a serotonin re-uptake inhibitor, this implies that the desired effect of MDMA may be enjoyed without its neurotoxic effects.

Three were experienced MDMA users who took 20mg fluoxetine 40-60 minutes before large doses of MDMA, 300-450 mg including booster doses. The sense of euphoria and closeness was unaffected. There was a greater sense of calmness but less increase in energy. Side effects normally felt such as jaw clench were less than normal, though nausea was worse. Two found it easier to sleep afterwards. Next-day fatigue was considerably less than normal, even for the one who found sleep as difficult as usual.

The fourth was a woman who had been taking 20mg fluoxetine for the previous 10 days. It was her first MDMA experience and her description of it was typical, implying that fluoxetine did not effect it.

The paper concludes that these cases "argue against the view that serotonin release is the basis for MDMA's psychoactive action", since this is prevented by pre-treatment with fluoxetine. This is supported by the fact that drugs such as fenfluramine do not produce similar psychoactive effects to MDMA.

[Contents][Appendix 1]
[Reference 183][Reference 185]
E is for Ecstasy by Nicholas Saunders (
HTMLized by Lamont Granquist (