The object of this study was to see whether MDMA use may produce long-term
psychological effects. Nine individuals were studied with extensive MDMA
use (twice a month for 5 years).
None of the 9 reported current psychiatric problems although 7 reported
previous periods in their lives when they suffered from anxiety or
depression. Most had family histories of alcohol or other substance abuse.
All sometimes also used other substances, although MDMA was there drug of
"Mental status examinations did not reveal any clinical impairments in
cognitive function, nor did neurological exams reveal any focal neurologic
"Performance in the Wechsler Memory Scale was subtly impaired in several
subjects" - but the amount of impairment did not correlate with the amount
of MDMA used. All but the heaviest user of MDMA showed at least mild
impairment in at least one neuropsychological function. However, none
showed affective or anxiety disorder or depression.
A note of caution adds that the sample was too small to draw definite
conclusions from, but the overall result was that heavy MDMA users probably
had slightly worse short-term memories, but were not depressed nor did they
show any other problems that might effect their lives.